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phenobarbital will minimize the extent or influence of olanzapine/samidorphan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Powerful CYP3A4 inducers lessen amounts of olanzapine and samidorphan by~fifty% and ~seventy five% respectively.sage decreases outcomes of phenobarbital by pharmacodynamic ant